新医学, 2021, 52(6): 454-457 doi: 10.3969/j.issn.0253-9802.2021.06.013

研究论著

加速康复外科临床路径在创伤骨科中的应用

马晋, 钟浩博, 樊仕才,

510600 广州,南方医科大学第三附属医院(广东省骨科医院)骨科(樊仕才)

Application of the clinical pathway of enhanced recovery after surgery (ERAS) in trauma and orthopedics

Ma Jin, Zhong Haobo, Fan Shicai,

Department of Orthopedics, the First People’s Hospital of Huizhou City, Huizhou 516003, China

通讯作者: 樊仕才,E-mail:69568870@qq.com

责任编辑: 林燕薇

收稿日期: 2021-01-11   网络出版日期: 2021-06-15

Corresponding authors: Fan Shicai, E-mail:69568870@qq.com

Received: 2021-01-11   Online: 2021-06-15

摘要

目的 探讨加速康复外科(ERAS)临床路径在创伤骨科患者围术期中的应用效果。方法 选择行手术治疗的100例老年髋部骨折、中青年桡骨远端骨折及踝关节骨折患者为研究对象,根据围术期是否行ERAS将患者分为非ERAS组与ERAS组,每组各50例。比较2组患者手术情况、术后恢复情况、VAS评分和并发症发生情况。结果 2组术中出血量、手术时间比较差异均无统计学意义(P均> 0.05)。与非ERAS组相比,ERAS组的首次进食时间和下床活动时间较早,住院时间较短,非手术住院费用明显减少(P均< 0.001)。术后第24 h、48 h,ERAS组患者VAS评分均低于非ERAS组(P均< 0.001),2组术后72 h VAS评分比较差异无统计学意义(P > 0.05)。ERS组的术后并发症总发生率低于非ERAS组(P < 0.001)。结论 ERAS应用于创伤骨科手术患者围术期管理中,能够缓解患者术后初期疼痛感,减少并发症发生,有助缩短康复进程,减轻患者的经济负担。

关键词: 创伤骨科 ; 加速康复外科 ; 临床路径 ; 围术期管理

Abstract

Objective To evaluate the effect of the clinical pathway of enhanced recovery after surgery (ERAS) in the perioperative management of orthopedic trauma patients.Methods A total of 100 elderly patients with hip fracture, young-and middle-aged patients with distal radius fracture and ankle joint fracture were recruited in this study. All 100 patients were evenly divided into the ERAS and non-ERAS groups according to whether ERAS was performed during perioperative period. Surgical condition, postoperative recovery, VAS score and incidence of postoperative complications were statistically compared between two groups. Results Intraoperative blood loss and operation time did not significantly differ between two groups (both P > 0.05). Compared with the non-ERAS group, the first feeding time and out-of-bed activity time were significantly earlier, the length of hospital stay was remarkably shorter and the nonsurgical hospitalization expense was considerably less in the ERAS group (all P < 0.001). At 24- and 48-h after operation, the VAS scores in the ERAS group were significantly lower than that in the non-ERAS group (both P < 0.001), whereas the VAS score at postoperative 72 h did not significantly differ between two groups (P > 0.05). The incidence of postoperative complications in the ERAS group was significantly lower than that in the non-ERAS group (P < 0.001). Conclusions Application of the clinical pathway of ERAS in the perioperative management of patients undergoing orthopedic trauma surgery can significantly relieve postoperative pain, lower the incidence of complications, shorten the rehabilitation process, and reduce the economic burden of patients.

Keywords: Orthopaedic trauma ; Enhanced recovery after surgery ; Clinical pathway ; Perioperative management

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本文引用格式

马晋, 钟浩博, 樊仕才. 加速康复外科临床路径在创伤骨科中的应用. 新医学[J], 2021, 52(6): 454-457 doi:10.3969/j.issn.0253-9802.2021.06.013

Ma Jin, Zhong Haobo, Fan Shicai. Application of the clinical pathway of enhanced recovery after surgery (ERAS) in trauma and orthopedics. Journal of New Medicine[J], 2021, 52(6): 454-457 doi:10.3969/j.issn.0253-9802.2021.06.013

加速康复外科(ERAS)理念为近年新兴的一种围术期管理理念,主要是以循证医学为依据,应用多模式医疗手段改良围术期管理流程,以减少患者心理、生理应激反应,促使患者快速康复[1]。当前,ERAS理念广泛应用于关节外科、消化外科、妇科、胸外科等外科手术,也有研究证实其能够减少患者术后并发症发生、缩短住院时间。创伤骨科收治的患者通常年龄跨度较大,疾病类型多种多样,且病情复杂,故更应该重视围术期的康复管理[2]。但目前创伤骨科尚无公认的ERAS方案。为此,本研究回顾性分析近年行手术治疗的100例老年髋部骨折、中青年桡骨远端骨折及踝关节骨折患者的临床资料,探讨ERAS临床路径在创伤骨科患者围术期中的应用效果,具体过程和结果报道如下。

对象与方法

一、研究对象

选择2018年9月至2019年3月在惠州市第一人民医院骨科行手术治疗的老年髋部骨折、中青年桡骨远端骨折及踝关节骨折患者为研究对象。病例纳入标准:①老年(≥65岁)髋部骨折患者,中青年(16 ~ 50岁)桡骨远端骨折及踝关节骨折患者;②经体格检查、X线或CT检查确诊为髋部骨折、桡骨远端骨折及踝关节骨折。排除标准:①合并其他部位骨折;②伤后时间超过3周;③伴有肿瘤转移性骨折、假体周围骨折;④伴有糖尿病及其他代谢性疾病、胃排空障碍、消化道完全性梗阻、重度心肾功能不全等疾病;⑤精神紊乱、酒精依赖、有药物滥用史。根据围术期是否行ERAS将患者分为非ERAS组与ERAS组,每组各50例,非ERAS组中,男36例、女14例,年龄59(23,78)岁,髋部骨折16例、桡骨远端骨折16例、踝关节骨折18例;ERAS组中,男33例、女17例,年龄59(20,79)岁,髋部骨折18例、桡骨远端骨折17例、踝关节骨折15例,2组患者的一般资料比较差异均无统计学意义(P均> 0.05)。本研究获得医院伦理委员会批准,且患者均已经签署知情同意书。

二、方 法

2组患者均进行切开复位内固定术治疗,在围术期非ERAS组采用常规临床路径处理,ERAS组采用ERAS临床路径处理,具体见表1

表1   非ERAS组与ERAS组围术期的处理

时 间项目非ERAS组ERAS组
术前生理评估根据患者实际病情和检查结果评估其手术风险及耐受性常规评估手术风险和耐受性,并对于有内科合并症患者要求相关科室会诊制定围术期诊疗方案,另加强营养状况评估,对于营养不良者,要求营养科门诊制定营养支持方案
健康教育书面告知患者、家属手术过程、手术风险及相关配合事项利用宣传册、微视频告知患者疾病、切开复位内固定术相关知识以及手术流程、手术安全性、术后可能并发症及处理、成功案例等,并介绍ERAS的相关内容、具体实施步骤等
术前用药术前预防性使用抗生素,常规予麻醉前用药术前预防性镇痛用药。但不使用镇静、抗胆碱药物,对于术前情绪紧张患者,予以短效抗焦虑药
消肿治疗不处理术前使用药物或者物理疗法促进患肢消肿,不推荐常规使用甘露醇
抗血栓治疗常规使用低分子肝素钠皮下注射抗凝在使用药物抗凝的基础上鼓励患肢尽可能活动和肌肉的等长收缩
饮食指导术前禁食12 h,禁饮 6 h麻醉前禁食6 h,禁饮2 h
肠道准备常规生理盐水灌肠不予以肠道准备,嘱患者低脂饮食
压疮预防根据实际情况尽量应用防压疮垫并进行规范的防压疮处理
牵引予皮牵引或骨牵引不予皮牵引或骨牵引
尿管放置术前放置尿管术前不放置尿管
术中心理疏导积极鼓励并安慰患者,以缓解其手术的紧张心理
术中保温应用棉被保暖,手术室室温控制在20 ~ 25℃在常规术中保温护理的基础上,对术中应用的输注液、冲洗液恒温保持37℃,且每1 h监测1次体温
术中补液术中不控制输液量、滴速术中合理控制补液量和滴速,避免输注过多过高渗液,特别是含钠液体
麻醉方法全身麻醉全身麻醉联合超声引导下区域阻滞
术后镇痛麻醉消退后根据患者主诉予以阿片类镇痛药麻醉消退前即开始予以患者自控持续镇痛,并在此基础上按流程进行阶梯化疼痛管理
饮食指导待肛门排气后可适量饮水、流质饮食,逐渐过渡到普食麻醉消退后可进饮,并逐步进食,逐渐恢复到普食
早期活动自愿活动鼓励患者术后尽早功能锻炼和活动,术后即可开始肢体肌肉收缩练习,在患者情况允许下可以坐起活动;术后首日可开始下床活动,手术侧肢体可以在患者疼痛耐受范围内负重
出院出院标准根据患者的意愿,或临床医师判断建议出院,无严格标准术后患者体温、常规化验指标无明显异常、伤口愈合佳(引流管拔除、伤口无感染征象)、X线片提示手术效果满意、没有需要住院处理的并发症和(或)合并症等

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三、观察内容

包括:①对比2组术中出血量、手术时间、术后首次进食时间、首次下床活动时间、住院时间、非手术住院费用的差异;②对比2组患者术后第24、48、72 h疼痛情况。选用视觉模拟评价法(VAS)进行疼痛程度评估,其分值在0 ~ 10分之间,得分越高,表示疼痛越剧烈;③对比2组术后并发症发生情况,包括压疮、下肢静脉血栓、肺部感染、尿路感染等[3]

四、统计学处理

使用SPSS 23.0处理数据。计数资料以例(%)描述,组间比较行x2检验或Fisher确切概率法。符合正态分布的计量资料以$\bar{x}\pm s$描述,组间比较行t检验,重复测量资料采用重复测量资料方差分析;非正态分布计量资料用M(P25,P75)表示,组间比较用Mann-Whitney U检验。P < 0.05为差异有统计学意义。

结果

一、ERAS组与非ERAS组患者的手术情况及术后恢复情况对比

2组患者的术中出血量、手术时间比较差异均无统计学意义(P均> 0.05)。与非ERAS组相比,ERAS组患者术后首次进食及首次下床活动时间均较早、住院时间较短、非手术住院费用减少(P均< 0.05),见表2

表2   ERAS组与非ERAS组患者的手术情况及术后恢复情况对比($\bar{x}\pm s$)

组 别例数术中出血量
(ml)
手术时间
(min)
术后首次进
食时间(h)
术后首次下床
活动时间(d)
术后住院时间
(d)
非手术住院费用
(元)
ERAS组5038.82±6.6162.26±7.644.94±1.581.00±0.0011.72±3.193974.82±587.75
非ERAS组5039.86±6.0564.70±8.066.88±1.172.86±0.6116.70±2.514833.30±635.75
t值0.8211.5536.96521.6888.6797.011
P值0.4140.124< 0.001< 0.001< 0.001< 0.001

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二、ERAS组与非ERAS组患者术后VAS评分对比

2组患者术后24、48、72 h的重复测量资料方差分析显示处理主效应与时间效应存在交互作用(F = 514.07,P < 0.001),因此采用t检验分析各时点间的组间差异。结果显示,ERAS组术后第24、48 h的VAS评分均低于非ERAS组(P均< 0.001),2组术后72 h VAS评分比较差异无统计学意义(P > 0.05),见 表3

表3   ERAS组与非ERAS组患者的术后VAS评分对比($\bar{x}\pm s$) 单位:分

组 别例数术后24 h术后48 h术后72 h
ERAS组502.68±0.961.98±0.711.84±0.62
非ERAS组505.06±1.133.18±0.831.80±0.54
t值11.3517.7750.346
P值< 0.001< 0.0010.730

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三、ERAS组与非ERAS组患者术后并发症发生情况对比

ERAS组术后仅有1例患者出现肺部感染,对照组出现压疮4例、下肢静脉血栓5例、肺部感染3例、尿路感染3例(无患者发生2种及以上并发症),ERAS组并发症总发生率低于非ERAS组(P < 0.001),见 表4

表4   ERAS组与非ERAS组患者的术后并发症发生情况对比[例(%)]

组 别例数压疮下肢静脉血栓肺部感染尿路感染总发生
ERAS组50001(2)01(2)
非ERAS组504(8)5(10)3(6)3(6)15(30)
P值a0.1180.0560.6170.079< 0.001

注:aFisher确切概率法

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讨论

创伤骨科收治的患者多为意外伤害导致的骨折疾病或多发性创伤,患者通常会在短期内丧失肢体或其他生理功能,同时伴有较为强烈的恢复正常工作、生活的需求,但骨科疾病的康复时间相对较长,往往与患者的需求相悖,再加上患者在围术期需要承受疼痛、饥饿、麻醉等多项生理应激,故其术后并发症发生风险也高,影响康复进程。因此,积极寻找一种科学的、合理的能够促进患者快速康复的诊疗模式至关重要。

ERAS理念由丹麦外科医师Kehlet首次提出,其主要是以循证医学、多学科协调为基础,促进患者术后快速康复的一种管理模式[4]。临床路径管理理念最早是在上世纪90年代提出且在全球范围内迅速普及应用,其在医疗服务中主要是根据临床诊治的时间节点,充分利用医院的硬件设施、人力资源对某一疾病的诊治流程进行规范化、标准化,以降低患者的治疗费用和医院的运行成本,使医患双方获益[5]。近年越来越多学者对ERAS在骨科手术中的应用进行跟进研究,并于2016年发表了《中国髋、膝关节置换术加速康复——围术期管理策略专家共识》[6]。这一指南为创伤骨科中普及ERAS奠定了基础。ERAS的有效开展需要手术室、麻醉科、临床科室的临床医师、护理人员密切配合,整合和多学科的医疗理念和医疗资源完成,可有效减少患者机体创伤应激,预防其并发症发生,进而加速康复进程[7,8]。本研究以循证医学证据为基础,将ERAS理念与临床路径相结合制定老年髋部骨折、中青年桡骨远端骨折及踝关节骨折患者围术期ERAS方案,充分将术前准备、术中管理、术后康复3个节点“环环相扣”,使医务人员能够高效率、高质量为患者提供医疗服务,有独特的临床优势。本研究也显示,与非ERAS组相比,ERAS组患者术后第24、48 h的VAS评分更低,且ERAS组术后并发症总发生率较低,首次进食时间、首次下床活动时间较早,住院时间较短,非手术住院费用明显减少,说明ERAS临床路径方案能够减轻患者术后痛苦,并可缩短其康复时间。

本研究遵循“术前-术中-术后-出院”流程制定加速康复临床路径计划,在术前加强与患者的沟通,向其针对性讲解疾病手术治疗及预计效果,提高患者治疗信心,增强手术配合度,而且在术前加强评估患者的营养状况和内科疾病的改善,提高其对手术的耐受性,并做好感染、深静脉血栓、压疮等预防工作,保障手术顺利进行。同时,术中使用全身麻醉联合超声引导下区域阻滞,减少术中镇痛药物的应用以缩短患者术后麻醉恢复时间,这对术后功能锻炼与康复具有显著益处。此外,术后采用多模式镇痛的方式显著减轻患者的疼痛感,使其能够积极配合进行早期活动锻炼,利于预防深静脉血栓、压疮等并发症发生,也对骨折愈合有促进作用。

综上所述,ERAS应用于创伤骨科手术患者围术期管理中,能够显著缓解术后初期疼痛感,减少并发症发生,有利于缩短康复进程,并可以减轻患者的经济负担,值得推广应用。

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李正碧, 刘丽, 朱晓镝, 杜祥琴, 周敏, 杨酼素.

加速康复理念在脊柱手术围术期中的应用研究

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汪晓俊, 陈莹, 张育奇, 林云云.

快速康复外科理念的推进对创伤骨科手术患者围术期疼痛管理的影响

国际护理学杂志, 2019, 38(20):3388-3391.

[本文引用: 1]

Feldheiser A, Aziz O, Baldini G, Cox BP, Fearon KC, Feldman LS, Gan TJ, Kennedy RH, Ljungqvist O, Lobo DN, Miller T, Radtke FF, Ruiz Garces T, Schricker T, Scott MJ, Thacker JK, Ytrebø LM, Carli F.

Enhanced recovery after surgery (ERAS) for gastrointestinal surgery, part 2: consensus statement for anaesthesia practice

Acta Anaesthesiol Scand, 2016, 60(3):289-334.

DOI:10.1111/aas.12651      PMID:26514824      [本文引用: 1]

The present interdisciplinary consensus review proposes clinical considerations and recommendations for anaesthetic practice in patients undergoing gastrointestinal surgery with an Enhanced Recovery after Surgery (ERAS) programme. Studies were selected with particular attention being paid to meta-analyses, randomized controlled trials and large prospective cohort studies. For each item of the perioperative treatment pathway, available English-language literature was examined and reviewed. The group reached a consensus recommendation after critical appraisal of the literature. This consensus statement demonstrates that anaesthesiologists control several preoperative, intraoperative and postoperative ERAS elements. Further research is needed to verify the strength of these recommendations. Based on the evidence available for each element of perioperative care pathways, the Enhanced Recovery After Surgery (ERAS®) Society presents a comprehensive consensus review, clinical considerations and recommendations for anaesthesia care in patients undergoing gastrointestinal surgery within an ERAS programme. This unified protocol facilitates involvement of anaesthesiologists in the implementation of the ERAS programmes and allows for comparison between centres and it eventually might facilitate the design of multi-institutional prospective and adequately powered randomized trials. © 2015 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

Melloul E, Hübner M, Scott M, Snowden C, Prentis J, Dejong CH, Garden OJ, Farges O, Kokudo N, Vauthey JN, Clavien PA, Demartines N.

Guidelines for perioperative care for liver surgery: enhanced recovery after surgery (ERAS) society recommendations

World J Surg, 2016, 40(10):2425-2440.

DOI:10.1007/s00268-016-3700-1      URL     [本文引用: 1]

周宗科, 翁习生, 曲铁兵, 张先龙, 严世贵, 曹力, 朱振安, 廖威明, 钱齐荣, 杨柳, 朱庆生, 吴海山, 史占军, 黄伟, 赵建宁, 钱文伟, 廖刃, 刘斌, 孙学礼, 王坤正, 邱贵兴, 裴福兴.

中国髋、膝关节置换术加速康复——围术期管理策略专家共识

中华骨与关节外科杂志, 2016, 9(1):1-9.

[本文引用: 1]

Berg U, Berg M, Rolfson O, Erichsen-Andersson A.

Fast-track program of elective joint replacement in hip and knee-patients’ experiences of the clinical pathway and care process

J Orthop Surg Res, 2019, 14(1):186.

DOI:10.1186/s13018-019-1232-8      URL     [本文引用: 1]

Sihoe AD, Yu PS, Kam TH, Lee SY, Liu X.

Adherence to a clinical pathway for video-assisted thoracic surgery: predictors and clinical importance

Innovations (Phila), 2016, 11(3):179-186.

DOI:10.1097/IMI.0000000000000279      PMID:27537191      [本文引用: 1]

A bespoke clinical pathway is increasingly often used to expedite patient's recovery after video-assisted thoracoscopic surgery (VATS). The importance and predictors of adherence to a clinical pathway have not been previously investigated. A defined clinical pathway was used for the perioperative management of 136 consecutive patients receiving major pulmonary resection surgery. The clinical pathway encompassed multiple aspects of clinical care, including chest drainage, analgesia, mobilization, physiotherapy, investigations, etc. The cohort consisted of 76 males (56%), and had a median age of 61 years (range, 14-84). A single lobectomy was performed in 66 patients (49%), with sublobar or more complex resections performed in the remainder. Although all patients were intended for a VATS approach, VATS was ultimately used to complete the procedure in 113 patients (83%). It was impossible to adhere strictly to the clinical pathway throughout the hospital stay of most patients, with 83 patients (61%) found to have adhered to the clinical pathway for 50% or more or the duration of their in-hospital stay. The rate of adherence to the clinical pathway for 50% or more of the time was lower in patients who were male (31.6% vs 48.3%, P = 0.047); had a smoking history (25.9% vs 47.6%, P = 0.011); and did not have absence of pain immediately after surgery (33.9% vs 59.3%, P = 0.016). There were trends for poorer adherence among patients who had: age older than 65 years; previous tuberculosis; body mass index greater than 25 kg/m; and longer operation times-but these failed to reach statistical significance. The approach and extent of surgery did not influence clinical pathway adherence. Adherence for 50% or more of the hospital stay was associated with reduced mean chest drain duration (3.2 ± 1.7 vs 5.1 ± 5.0 days, P = 0.002) and mean length of stay (4.6 ± 1.9 vs 7.9 ± 6.6 days, P < 0.001). Among smokers, adherence for 75% or more of the hospital stay was particularly well predicted by better pain control on the day of surgery, and was in turn associated with a significant reduction in morbidity rate (7.7% vs 39.0%, P = 0.043). Good adherence to a detailed clinical pathway may ensure faster recovery after VATS but is often difficult to maintain postoperatively. Predictors of poor adherence include male sex, smoking history, and immediate postoperative pain. Smokers are at particular risk for failure to adhere but paradoxically have the most to gain from adhering to the clinical pathway.

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