Advances in novel imaging agents targeting fibroblast activation proteins

Based on the high target-to-background ratio（TBR）,new imaging agents targeting fibroblast activation protein（FAP）have shown better imaging effects in a variety of tumors. In recent years,with in-depth research,FAP inhibitor（FAPI）has shown great application prospects in tumor imaging and treatment. It can be used as a supplement to the mainstream metabolic imaging agent ¹⁸F-labeled fluorodeoxyglucose（¹⁸F-FDG）,which provides the possibility of more efficient combination of tumor metabolism and tumor stroma visualization in the future. It is helpful to guide clinical diagnosis and treatment more accurately. This article mainly reviews the application of new FAP imaging agents in various tumors,compares them with existing radiological diagnostic methods,and summarizes the clinical application progress and future potential of tracers specifically targeting FAPI in tumors and non-specific tissues.