Function of non-coding RNA in radioresistance in non-small cell lung cancer

Lung cancer is not only one of the most common malignancies,but also has the highest mortality rate worldwide,among which non-small cell lung cancer（NSCLC）is the most common subtype. Radiation therapy is one of the main treatments for patients with advanced NSCLC,and the resistance generated during long-term treatment is the key to radiation therapy failure and poor prognosis. With the widespread application of whole genome and RNA sequencing technology and the in-depth exploration of the biological functions of non-coding RNA（ncRNA）,there is growing evidence that ncRNA are key regulators in tumorigenesis and development,and different ncRNAs play a role in promoting or inhibiting tumor radioresistance,which are expected to become a useful markers for tumor diagnosis and new targets for tumor treatment. In this article,recent research progress in ncRNA such as microRNA（miRNA）,long non-coding RNA（lncRNA）,and circular RNA（circRNA）in the radioresistance of NSCLC was reviewed.