Application value of multi-dimensional combined ultrasonography in prenatal diagnosis of fetal malformation in southern Xinjiang Uygur autonomous region

Objective To explore the application value of multi-dimensional ultrasonography （2D, 3D combined with 4D） in the prenatal diagnosis of fetal malformation in southern Xinjiang Uygur autonomous region. Methods Seventy-seven Uygur pregnant women diagnosed with fetal malformations by multi-dimensional ultrasonography, induced labor or follow-up were selected from 14 642 Uygur pregnant women and enrolled in this study. The ultrasound data of these 77 cases were obtained. The diagnostic rate of fetal malformation was statistically compared between 2D and multi-dimensional combined ultrasonography. Results Among 77 cases of fetal malformations, skull surface deformity occurred in 10 cases, spinal deformity in 9 cases, neurological deformity in 6 cases, limb deformity in 35 cases, mixed malformations （≥two types of malformations） in 17 cases, respectively. The diagnostic rate of fetal malformation by 2D ultrasonography was 73% （56/77）, significantly lower than that of 92% （71/77） （P < 0.05）. Conclusion Multi-dimensional combined ultrasonography can effectively improve the diagnostic rate for fetal malformation, which is of significant application value.