Comparison of diagnositc values between 3.0T functional DCE- and DWI-MRI in cervical cancer

Objective To investigate the values of 3.0T functional dynamic contrast-enhanced （DCE）- and diffusion-weighted imaging （DWI）-magnetic resonance imaging （MRI） in the diagnosis of cervical cancer. Methods Eighty-one patients suspected with malignant cervical lesions or pelvic lesions without cervical lessions were recruited to receive pelvic MRI. Among them, 29 patients were diagnosed with cervical cancer, 25 cases of uterine leiomyoma and 27 cases of normal uterus. All patients were subject to routine, DCE- and DWI-MRI of the pelvis. Various parameters including Ktrans, Kep, Ve, iAUC and ADC were obtained. The ROC curve analysis was conducted to compare the analysis results between DWI- and DCE-MRI. Results The Ktrans, Kep, Ve and iAUC parameters in patients with cervical cancer were significantly higher, whereas the ADC value was remarkably lower compared with those in their counterparts with uterine leiomyoma and normal uterus （all P < 0.05）. The area under the ROC curve （AUC） of different parameters in the diagnosis of cervical cancer was 0.836 for Ktrans, 0.742 for Kep, 0.663 for Ve and 0.698 for iAUC, respectively. The AUC of ADC value of DWI in the diagnosis of cervical cancer was calculated as 0.970, significantly higher than 0.836 of Ktrans （P < 0.05）. Conclusion In the diagnosis of cervical cancer, the ADC value of 3.0T functional DWI-MRI has higher diagnostic efficiency compared with alternative DCE-MRI parameters.