Ovarian cancer associated with Lynch syndrome: a case report

Lynch syndrome, also known as hereditary non-polyposis colorectal cancer （HNPCC）, is an autosomal dominant inherited cancer susceptibility syndrome. It is caused by the mutations in the DNA mismatch repair （MMR） genes, such as MLH1, MSH2, MSH6 and （or） PMS2. MMR gene mutation can also increase the risk of ovarian cancer. In this article, the diagnosis and treatment of one case of Lynch syndrome-associated ovarian cancer were reported. Auxiliary examination of this patient indicated a high possibility of ovarian cancer. Postoperative immunohistochemical staining suggested that it might be complicated with Lynch syndrome, which was finally confirmed by genetic examination. Lynch syndrome is a hereditary tumor syndrome, and it is prone to occur at the same time or at different time in different parts of malignant tumors. Clinicians should improve the awareness of this disease, enhance the awareness of early screening and improve the level of diagnosis and treatment.