Acquired hypophosphatemic osteomalacia: a report of two cases

Hypophosphatemic osteomalacia is a rare metabolic bone disease, which can be divided into the genetic, tumorous and acquired types according to the etiology. Clinical manifestations include bone pain and bone fracture, etc. It is likely to be misdiagnosed or miss diagnosis. In this article, we reported two cases （37-year-old male and 33-year-old female） of acquired hypophosphatemic osteomalacia. Two patients were admitted to our hospital due to chief complaint of bone pain. After the diagnosis of hypophosphatemic osteomalacia was confirmed, the cause of disease was further identified. One patient was diagnosed with medicine-induced hypophosphatemic osteomalacia. The other patient was diagnosed with hypophosphatemic osteomalacia secondary to Sjögren's syndrome complicated with renal tubular acidosis. The clinical characteristics, differential diagnosis and treatment of two patients were subsequently analyzed, aiming to provide novel ideas for the diagnosis and treatment of acquired hypophosphatemic osteomalacia for the clinicians.