Abstract: Immunotherapy has achieved good efficacy in clinical anti-tumor therapy, especially chimeric antigen receptor T cell （CAR-T cell） therapy, as an emerging tumor immunotherapy, has achieved breakthrough efficacy in the clinical treatment of hematologic malignancies. However, CAR-T cell face the problem of gradual exhaustion during the treatment process, especially in the treatment of solid tumors, which will lead to poor anti-tumor efficacy and possible risks such as recurrence. This paper analyzed the possible mechanism of CAR-T cell exhaustion and describes the relevant research progress in inhibiting CAR-T cell exhaustion, with a view to designing reasonable therapeutic strategies to reduce CAR-T cell exhaustion and improve the efficacy of CAR-T cell.