过敏性鼻炎的中医药治疗机制及免疫调控途径研究

Study on the therapeutic mechanism of traditional Chinese medicine and immune regulation pathway of allergic rhinitis

  • 摘要: 过敏性鼻炎(AR)是一种由免疫球蛋白E(IgE)介导的Ⅰ型超敏反应,涉及多种免疫细胞和炎症因子。西医治疗在缓解AR症状方面具有一定成效,但其局限性促使越来越多的研究将目光转向中医药治疗。中医认为,AR的发生与肺、脾、肾功能失调有关,治疗原则包括扶正祛邪、清热解毒以及调和阴阳等。研究表明,中医药通过调节辅助性T细胞(Th)1/Th2平衡、增强调节性T细胞的功能、抑制IgE介导的过敏反应、减少炎症细胞浸润及调控NF-κB、MAPK和JAK/STAT等信号通路,发挥其免疫调节和抗炎作用。中医药在AR治疗中的多靶点作用机制为症状改善和复发预防提供了有效的治疗策略。文章综述了中医药在治疗AR中的作用机制及相关研究进展,旨在进一步优化其临床应用价值。

     

    Abstract: Allergic rhinitis (AR) is a type Ⅰ hypersensitivity reaction mediated by immunoglobulin E (IgE), involving multiple immune cells and inflammatory factors. Western medicine has achieved certain effects in alleviating AR symptoms, but its limitations have led more and more studies to focus on traditional Chinese medicine (TCM) treatment. According to TCM theory, the occurrence of AR is related to the dysfunction of the lung, spleen and kidney. The treatment principles include strengthening the body’s resistance, eliminating pathogenic factors, clearing heat and detoxifying, and harmonizing Yin and Yang. Studies have shown that Chinese medicine exerts its immunomodulatory and anti-inflammatory effects by regulating the balance of T helper cells (Th) 1/Th2, enhancing the function of regulatory T cells, inhibiting IgE-mediated allergic reactions, reducing inflammatory cell infiltration, and regulating NF-κB, MAPK and JAK/STAT signaling pathways. The multi-target mechanism of Chinese medicine in the treatment of AR provides an effective therapeutic strategy for symptom improvement and recurrence prevention. This article reviews the mechanism of action and related research progress of TCM in the treatment of AR, aiming to further optimize its clinical application value.

     

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