Abstract:
Allergic rhinitis (AR) is a type Ⅰ hypersensitivity reaction mediated by immunoglobulin E (IgE), involving multiple immune cells and inflammatory factors. Western medicine has achieved certain effects in alleviating AR symptoms, but its limitations have led more and more studies to focus on traditional Chinese medicine (TCM) treatment. According to TCM theory, the occurrence of AR is related to the dysfunction of the lung, spleen and kidney. The treatment principles include strengthening the body’s resistance, eliminating pathogenic factors, clearing heat and detoxifying, and harmonizing Yin and Yang. Studies have shown that Chinese medicine exerts its immunomodulatory and anti-inflammatory effects by regulating the balance of T helper cells (Th) 1/Th2, enhancing the function of regulatory T cells, inhibiting IgE-mediated allergic reactions, reducing inflammatory cell infiltration, and regulating NF-κB, MAPK and JAK/STAT signaling pathways. The multi-target mechanism of Chinese medicine in the treatment of AR provides an effective therapeutic strategy for symptom improvement and recurrence prevention. This article reviews the mechanism of action and related research progress of TCM in the treatment of AR, aiming to further optimize its clinical application value.