Abstract: Mouth breathing（MB） is a common abnormal breathing pattern in children, and prolonged MB may lead to numerous health problem, especially unfavourable to the development of children’s teeth and jaws, speech and nerves. In recent years, intelligent healthcare represented by artificial intelligence （AI） has gradually been applied to the diagnosis and treatment of MB, demonstrating unique advantages of modern technology in early screening, treatment modality selection, and treatment effect evaluation for MB. In this article, we reviewed the recent literature and elaborate the application of intelligent technology in the diagnosis and treatment of MB, with the aim of more fully understanding the opportunities and challenges of intelligent diagnosis and treatment of MB, breaking down the boundaries of disciplines, and carrying out a wide range of ‘medical-industrial integration’ research, so as to benefit more children with MB.