Abstract: Objective To explore the influence factors of visual impairment and recovery in patients with central retinal vein occlusion （CRVO） complicated with macular edema （ME）. Methods One hundred patients who were initially diagnosed with CRVO-ME and phlegm and blood stasis syndrome based on traditional Chinese medicine in Eye Hospital, China Academy of Chinese Medical Sciences were involved. They were treated with Quji Tongluo Decoction combinied with intravitreal ranibizumab injections. At baseline and 90 days after treatment, optical coherence tomography angiography （OCTA） was used to measure the vascular density （VD） of optic disc （VD in the whole optic disc scanning area, VD inside disc and peripapillary VD optic disc）, the thickness of the retinal nerve fiber layer （RNFL）, the vertical cup / disc ratio （C/D）, the area of the optic disc, the volume of the optic cup, VD of the superficial capillary plexus （SCP） and the deep capillary plexus in the macula, and central macular thickness （CMT）. Results After treatment, best corrected visual acuity（BCVA （LogMAR））, RNFL thickness, VD in the whole optic disc scanning area, VD inside disc, peripapillary VD, DCP-VD and CMT had significant differences before and after treatment （all P < 0.05）. At baseline, BCVA （LogMAR） was significantly correlated with VD in the whole optic disc scanning area （r_s = -0.294, P =0.003）, VD inside disc, optic disc （r_s = -0.401, P < 0.001）, peripapillary VD （r_s = -0.315, P = 0.001）, SCP-VD （r_s = -0.291, P = 0.003）, DCP-VD （r_s = -0.258, P = 0.009）, and CMT （r_s = 0.334, P = 0.001）. Multivariate linear regression analysis showed that VD within the optic disc （B = -0.045, P < 0.001） and CMT （B = 0.001, P = 0.018） had a significant impact on visual acuity. After treatment, the changes of BCVA （LogMAR） were correlated with the changes of VD in the whole optic disc scanning area （r_s =-0.226, P = 0.024）, VD within the optic disc （r_s = -0.284, P = 0.004） and CMT （r_s = 0.241, P = 0.016）. Multivariate linear regression analysis showed that the changes of VD within the optic disc （B = -0.028, P = 0.006） and CMT （B = 0.001, P = 0.023） had a significant impact on the improvement of visual acuity. Conclusion The blood flow perfusion of the main vessels in the optic disc is of significance for the occurrence and recovery of CRVO. VD within the optic disc could be used as a new biomarker evaluating visual impairment and prognosis.