Abstract: This consensus was developed to standardize clinical nursing practice for adult patients with non-HIV-associated cryptococcal meningitis, with the goal of enhancing the quality of care and improving patient prognosis. The development process involved systematic evidence retrieval from major Chinese and English databases, supplemented by in-depth interviews with clinical specialists, leading to the formulation of a preliminary draft. Subsequent revisions through two rounds of Delphi expert consultations and one multidisciplinary panel meeting culminated in the finalized consensus. The framework encompasses six critical domains： comprehensive nursing assessment, intravenous therapy and pharmacotherapeutic management, nursing care for related symptoms, perioperative nursing care, prevention and management of common complications, and structured rehabilitation. Particular emphasis is placed on holistic patient evaluation, tailored therapeutic drug monitoring, early recognition of complications, and integrated rehabilitative continuity. This consensus seeks to deliver an evidence-based, standardized operational framework for specialized nursing practice, thereby safeguarding therapeutic efficacy and promoting excellence in patient care.