Abstract: In response to the clinical needs and patient expectations regarding adult enterostomy care in China, the Wound, Ostomy and Continence Nursing Committee of Chinese Nursing Association cooperated with Professional Committee of Integrated Nursing for Colorectal Cancer of China Anti-cancer Association and Evidence-based Nursing Center of Peking University Health Science Center to organize a panel of national experts in relevant field to form a guideline development team. Following the WHO Handbook for Guideline Development, the team systematically reviewed literature and conducted rigorous quality assessments addressing defined clinical issues. Through expert consensus meetings, recommendations were formulated, and the initial draft of the Guideline for Adult Enterostomy Care （hereinafter referred to as the Guideline） was prepared. The draft Guideline underwent review by 24 experts from various regions across China. Based on their feedback, the Guideline was revised, and a final expert meeting was convened to formulate the final version. The finalized Guideline covers four major aspects： preoperative care, postoperative care, rehabilitation care, and management of enterostomy and peristomal skin complications, comprising a total of 89 recommendations. Based on the best evidence available, current domestic clinical practices, and professional judgment, the Guideline is highly scientific and practical, which can be applied to guide clinical practice in adult enterostomy care.