儿童社区获得性肺炎肺外并发症早期预警指标研究进展

Research progress on early warning of extrapulmonary complications in pediatric community-acquired pneumonia

  • 摘要: 儿童社区获得性肺炎(community acquired pneumonia,CAP)是威胁全球儿童健康的重要感染性疾病,其肺外并发症可累及多系统,显著增加疾病重症率及死亡风险。儿童CAP肺外并发症的发病机制复杂多样,不同病原体的致病机制也存在差异,免疫介导损伤与炎症因子风暴的相互促进,是重症CAP引发多系统肺外并发症的核心病理环节。文章系统综述了儿童CAP肺外并发症发生的流行病学特征、病理生理机制、危险因素研究进展,重点探讨消化系统、心血管系统、神经系统、血液系统、皮肤黏膜等系统的受累特点、危险因素,分析不同病原体致CAP肺外并发症的预警指标,旨在为儿童CAP肺外并发症早期识别和精准干预提供参考依据。

     

    Abstract: Pediatric ommunity-acquired pneumonia (CAP) is a significant infectious disease that threatens the health of children worldwide. Its extrapulmonary complications can affect multiple systems, significantly increasing the risk of severe disease and mortality. The pathogenesis of extrapulmonary complications in paediatric CAP is complex and diverse, with differences in the pathogenic mechanisms of different pathogen. The mutual promotion of immune-mediated damage and the inflammatory cytokine storm is a core pathological event leading to multisystem extrapulmonary complications in severe CAP. This article systematically reviews the epidemiological characteristics, pathophysiological mechanisms, risk factors, and diagnostic and therapeutic progress of extrapulmonary complications in paediatric CAP. It focuses on the characteristics of involvement and risk factors in the digestive, cardiovascular, neurological, haematological, and cutaneous-mucosal systems, and analyzes the early warning indicators of extrapulmonary complications in CAP caused by different pathogens, aiming to provide a reference for the early identification and precise intervention of extrapulmonary complications in paediatric CAP.

     

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