Abstract: Sepsis is a frequent, complicated and highly lethal disease in intensive care units. The main cause of mortality in sepsis patients is multiple organ dysfunction syndrome （MODS） caused by an explosive systemic inflammatory response. Some patients with sepsis may experience hypoalbuminemia, hypotension, oliguria, edema and MODS, namely capillary leakage syndrome （CLS）. The multi-system and uncontrollable CLS induced by the release of inflammatory mediators is the primary cause of MODS. The main pathophysiological mechanism of CLS is the increase of vascular permeability caused by hypercytokine. Fluid resuscitation is an essential part of treatment for CLS patients. Deep understanding of the pathophysiological mechanism of sepsis with CLS is of significance for clinical practice.