Abstract: Objective To investigate the predictive value of Life’s Simple 7 score for the recurrence of atrial fibrillation after radiofrequency ablation. Methods Seventy-one patients with paroxysmal atrial fibrillation undergoing radiofrequency ablation were recruited and randomly divided into the control （n = 35） and LS7 intervention groups （n = 36）. LS7 score assessment was performed between two groups. Patients in the control group were treated with anti-arrhythmia, anti-coagulation and related diseases after operation, and those in the LS7 group were given with comprehensive intervention according to average and poor LS7 scores based on the treatment in the control group. Before and 12 months after corresponding interventions, cardiovascular health score （LS7 score）, cardiac color Doppler ultrasound parameters, systolic and diastolic blood pressure, C-reactive protein （CRP）, NT-proBNP, blood glucose, blood lipid were measured and compared between two groups. The CHA2DS2-VASc and LS7 scores were calculated in two groups. The recurrence rate of atrial fibrillation after radiofrequency ablation was statistically compared between two groups. Results The CRP and NT-ProBNP levels in the LS7 group were significantly declined after treatment （both P < 0.05）. In the LS7 group, CRP and NT-ProBNP levels, diastolic blood pressure, fasting blood glucose, total cholesterol, low-density lipoprotein （LDL-C） and body mass index （BMI） were significantly lower than those in the control group （all P < 0.05）. In the LS7 group, the total LS7 score was remarkably higher, whereas the postoperative recurrence rate of atrial fibrillation was significantly lower compared with those in the control group after treatment （both P < 0.05）. Conclusion LS7 comprehensive intervention can effectively improve the cardiovascular status after radiofrequency ablation and prevent the postoperative recurrence of atrial fibrillation in atrial fibrillation patients.