Abstract: Objective To investigate whether compound lidocaine cream can relieve catheter-related bladder discomfort （CRBD） in male patients undergoing lower urinary tract surgeries. Methods Eighty adult male patients undergoing elective lower urinary tract surgeries and postoperative indwelling 20# or 22# three-lumen urinary catheter under general anesthesia were randomly allocated into the cream （n = 40） and control groups （n = 40）. Patients in the cream group were applied with 5 g compound lidocaine cream at the front of the catheter to assist catheterization, and those in the control group received routine catheterization. The heart rate and mean blood pressure were recorded before the induction of anesthesia （T1）, at the end of surgery （T2）, at 5 min（T3）, 30 min（T4） and 2 h（T5） after laryngeal mask removal. The incidence and severity of CRBD were assessed at 5 min, 30 min and 2 h after laryngeal mask removal. Results At T3 and T4, the heart rate and mean blood pressure in the cream group were significantly lower than those in the control group （both P < 0.05）. At T3 and T4, the incidence of moderate to severe CRBD in the cream group was significantly lower compared with that in the control group （both P < 0.05）. Conclusions Urethral catheterization with compound lidocaine cream can reduce the incidence of moderate to severe CRBD within postoperative 2 h in male patients undergoing lower urinary tract surgeries and indwelling 20# or 22# three-lumen urinary catheter under general anesthesia, and stabilize the hemodynamics during the recovery period of general anesthesia.