Abstract: Kidney disease is the most common event among extrahepatic injuries caused by hepatitis C virus （HCV） infection. Meantime, the risk of HCV infection can be increased when chronic renal disease progresses into the end-stage renal disease requiring hemodialysis. Chronic hepatitis C （CHC） complicated with kidney disease can accelerate the progression of disease, leading to poor clinical prognosis. In this article, research progresses on the mechanism of renal disease caused by HCV and direct antiviral treatment for patients with chronic kidney disease complicated with CHC were reviewed, aiming to deepen clinicians’ understanding of delivering antiviral treatment for CHC patients complicated with kidney disease and enhance clinical prognosis.