Abstract: Objective To evaluate the effect of core muscle group activation combined with trunk control training on the motor function of children with cerebral palsy. Methods Clinical data of 40 children with cerebral palsy were collected and randomly divided into the observation （n = 20） and control groups （n = 20）. Children in the control group received trunk training on the basis of routine exercise therapy, and their counterparts in the observation group received trunk training in combination with core musde group activation training. The Gross Motor Function Measure （GMFM） score, Berg Balance Scale （BBS） score, modified Barthel Index （MBI） score, walking speed and degree of family satisfaction were recorded and statistically compared between two groups. Results Before treatment, the BBS score, GMFM score （D zone and E zone）, MBI score and walking speed did not significantly differ between two groups （all P > 0.05）. After treatment, the GMFM score （D zone and E zone）,BBS score and MBI score significantly increased in both groups. The scores of BBS, GMFM （D zone and E zone） and MBI （89.41±7.32） in the observation group were significantly better than those in the control group （all P < 0.05）. The walking speed in the observation group was （33.15±4.33） m/min, significantly faster than （26.25±3.84） m/min in the control group （P < 0.05）. After corresponding treatment, the degree of family satisfaction in the observation group was 95%, significantly higher compared with 50% in the control group （P < 0.05）. Conclusion Core muscle group activation combined with trunk training rehabilitation treatment can effectively improve the motor function of children with cerebral palsy and elevate the degree of family satisfaction.