Abstract: Objective To explore the risk factors for the infection of multi-drug resistant Pseudomonas aeruginosa （MDRP） in patients with bronchiectasis, and to provide scientific basis for the rational application of antimicrobial agents and the reduction of multi-drug resistant bacteria （MDROs）. Method Retrospective analysis was performed on the data of patients who hospitalized with bronchiectasis associated with infection and isolated Pseudomonas aeruginosa （PA） from sputum culture. These cases were divided into MDRP group and non-MDRP group according to drug sensitivity results. Student’s-test, Chi-square test or Wilcoxon rank sum test was used to screen the clinical data, and then Logistic stepwise regression analysis was performed to explore the independent risk factors for MDRP infection. Results A total of 98 PA strains were collected, including 34 in the MDRP group and 64 in the non-MDRP group. Statistical analysis showed that hospitalization frequency in the recent one year （OR = 2.419,95%CI 1.559-3.752,P < 0.001）, ICU/RICU hospitalization history （OR = 4.486,95%CI 1.290-15.602,P = 0.018）, hemoptysis （OR = 4.702,95%CI 1.110-19.918,P = 0.036） were independent risk factors for MDRP infection. Conclusion Frequent hospitalization in the recent one year, ICU/RICU hospitalization history, hemoptysis are important risk factors for MDRP infection, and identification of these characteristics is beneficial to the prevention and treatment of MDRP.