Abstract: Objective To summarize the mutation characteristics of V-raf munine sarcom viral oncogene homolog （BRAF） V600E in Meizhou Hakka patients with thyroid carcinoma. Methods Clinical data and BRAF V600E detection results of 316 thyroid carcinoma patients from Meizhou Hakka area were collected. The relationship between BRAF V600E mutation and tumor characteristics was analyzed by univariate and multivariate logistic regression analyses. Results The overall BRAF V600E mutation rate was 75.3% （238/316） of thyroid carcinoma patients from Meizhou Hakka area, and 77.0% （238/309） for the mutation rate of papillary thyroid carcinoma. Univariate analysis suggested that patients with BRAF V600E mutation showed smaller tumor diameter, higher proportion of aspect ratio of > 1 and microcalcification, less proportion of lymph node metastasis in the VI and lateral cervical regions （all P < 0.05）. Multivariate logistic regression analysis indicated that BRAF V600E mutation was significantly associated with lymph node metastasis in the VI region （OR = 2.289, 95%CI = 1.283-4.081, P = 0.005）, ultrasonic echo （OR = 0.419, 95%CI = 0.209-0.841, P = 0.014） and gross calcification （OR = 3.673, 95%CI = 1.395-9.668, P = 0.008）. Conclusion The BRAF V600E mutation rate of thyroid carcinoma patients from Meizhou Hakka area is relatively high. BRAF V600E mutation is prone to lymph node metastasis in the VI region.