Abstract: Objective To evaluate the effect of the clinical pathway of enhanced recovery after surgery （ERAS） in the perioperative management of orthopedic trauma patients. Methods A total of 100 elderly patients with hip fracture, young-and middle-aged patients with distal radius fracture and ankle joint fracture were recruited in this study. All 100 patients were evenly divided into the ERAS and non-ERAS groups according to whether ERAS was performed during perioperative period. Surgical condition, postoperative recovery, VAS score and incidence of postoperative complications were statistically compared between two groups. Results Intraoperative blood loss and operation time did not significantly differ between two groups （both P > 0.05）. Compared with the non-ERAS group, the first feeding time and out-of-bed activity time were significantly earlier, the length of hospital stay was remarkably shorter and the nonsurgical hospitalization expense was considerably less in the ERAS group （all P < 0.001）. At 24- and 48-h after operation, the VAS scores in the ERAS group were significantly lower than that in the non-ERAS group （both P < 0.001）, whereas the VAS score at postoperative 72 h did not significantly differ between two groups （P > 0.05）. The incidence of postoperative complications in the ERAS group was significantly lower than that in the non-ERAS group （P < 0.001）. Conclusions Application of the clinical pathway of ERAS in the perioperative management of patients undergoing orthopedic trauma surgery can significantly relieve postoperative pain, lower the incidence of complications, shorten the rehabilitation process, and reduce the economic burden of patients.