Abstract: Lymphatic leakage is a rare postoperative complication of gynecological tumor surgery, which is mainly characterized by abdominal drainage of chylous or yellowish fluid. It is difficult to make diagnosis and no standard therapeutic regime has been determined. In this article, the patient presenting with recurrent massive peritoneal effusion at a month after ovarian cancer surgery was reported. Upon admission, the patient was complicated with peritonitis. The possibility of chylous leakage was excluded by auxiliary examination. The patient was diagnosed with postoperative lymphatic leakage complicated with infection. After diagnostic treatment, relevant symptoms were significantly improved and the patient was discharged from hospital. Combined with relevant literature review, clinical data of this case were analyzed and summarized. Typical clinical manifestations and research progress on the diagnosis and treatment of lymphatic leakage were illustrated, aiming to provide evidence for the diagnosis and treatment of this disease.