Abstract: Objective To evaluate the clinical value of amplitude-integrated electroencephalogram （aEEG） in evaluating clinical prognosis and brain function of patients with hypertensive cerebral hemorrhage complicated with cerebral hernia. Methods Clinical data of 26 patients with postoperative hypertensive cerebral hemorrhage complicated with cerebral hernia were retrospectively analyzed. Baseline clinical data, acute physiology and chronic health evaluation systemⅡ（APACHE Ⅱ） score, Glasgow coma scale （GCS） and aEEG data within postoperative 6 h were recorded. The patients’ status at the time of transfer from ICU and clinical prognosis of brain function at 1 month after transfer from ICU （（Glasgow-Pittsburgh brain function score （CPC）） were regarded as the main clinical outcomes. Spearman rank correlation was used to analyze the relationship among aEEG,GCS, APACHEⅡand their correlation with clinical prognosis and brain function prognosis. Results Among 26 patients, 23 cases were male and 3 female, aged （59.4±8.61） years on average. Seven patients obtained preoperative Glasgow score of 3, 16 cases of 4-8 and 3 cases of 9-15. Eleven patients had APACHEⅡscore of <15, 11 cases of 16-30 and 4 cases of > 31. Five patients had normal aEEG （Grade I）, 10 cases of moderately abnormal aEEG （Grade Ⅱ） and 11 cases of severely abnormal aEEG （Grade Ⅲ）. A total of 18 cases survived and 8 died. Among 18 surviving patients, the prognosis of brain function was good （CPC score of 1-2） in 6 patients, and poor prognosis of brain function （CPC sore of 3-4 score） was observed in 12 cases. Preoperative APACHEⅡ score did not significantly differ between the survival and death groups （P > 0.05）, whereas the aEEG grade and preoperative GCS score significantly differed between two groups （both P < 0.05）. Preoperative APACHEⅡ and GCS scores did not significantly differ between the good and poor prognosis of brain function groups （both P > 0.05）, whereas the aEEG grade significantly differed between two groups （P < 0.05）. Conclusion aEEG technique can accurately reflect the postoperative brain function of patients with hypertensive cerebral hemorrhage complicated with cerebral hernia, which has important practical and clinical significance in predicting clinical prognosis and brain function prognosis.