Abstract: Objective To evaluate the prognostic value of geriatric nutritional risk index （GNRI） combined with clinical pulmonary infection score （CPIS） and inflammatory markers in elderly patients diagnosed with community-acquired pneumonia （CAP）. Methods A total of 237 elderly patients with CAP were recruited and divided into the following 4 groups： GNRI<92 and CPIS≥6 group （A group, n = 61）, GNRI<92 and CPIS<6 group （B group, n = 65）, GNRI≥92 and CPIS≥6 group （C group, n = 54） and GNRI≥92 and CPIS<6 group （D group, n = 57） according to the limits of GNRI≥92 and CPIS≥6. The length of hospital stay, mechanical ventilation rate, mortality rate, age, smoking history and underlying diseases （hypertension, coronary atherosclerotic heart disease, type 2 diabetes mellitus and renal insufficiency）, procalcitonin （PCT） and C-reactive protein （CRP） levels upon admission were statistically compared among different groups. The receiver operating characteristic （ROC） curve was delineated to compare the area under the ROC curve （AUC）, sensitivity and specificity of GNRI+CPIS and GNRI+CPIS+CRP+PCT in predicting the clinical prognosis of CAP patients. Results Age, smoking history and underlying diseases and length of hospital stay did not significantly differ among the 4 groups （all P > 0.05）. The mechanical ventilation rate, mortality rate, CRP and PCT significantly differed among the 4 groups （all P < 0.05）. The area under curve（AUC）, sensitivity and specificity of the combined score of GNRI+CPIS in predicting the risk of death in elderly patients with CAP was 0.805, 0.975 and 0.847, respectively. The AUC, sensitivity and specificity of GNRI+CPIS+CRP+PCT in predict the risk of death in elderly patients with CAP was 0.897, 0.983 and 0.906, respectively. The predictive value of the GNRI+CPIS+CRP+PCT model was significantly higher than that of the combined score of GNRI+CPIS （P < 0.001）. Conclusion Compared with GNRI+CPIS, GNRI+CPIS+CRP+PCT is more efficiency in predicting clinical prognosis of elderly patients with CAP.