Abstract: As the social competition intensifies, people’s life pressure is increasing and the incidence of insomnia is also being elevated. Clinically, long-term insomnia affects normal life and work of the patients. Due to physical and mental dysfunction, most patients will suffer from anxiety, depression and other symptoms, which further prevent the therapeutic effect. In this article, recent literature review was conducted to summarize the pathogenesis and integrated traditional Chinese and Western medicine treatment of insomnia complicated with anxiety and depression, aiming to enhance sleep quality, relieve anxiety and depression symptoms.