Abstract: Sarcoidosis is a systemic disease characterized by non-caseous epithelioid cell granuloma,which can involve with multiple organs,especially the lung. Sarcoidosis is characterized by diverse clinical manifestations and high incidence rate. Partial patients with pulmonary sarcoidosis can spontaneously relieve,whereas it is likely to recur after drug withdrawal. Some patients with fibrotic sarcoidosis persistently progress and obtain poor prognosis. Therefore,how to deliver clinical treatment is highly important and challenging. At present,although a preliminary consensus has been reached on the treatment of sarcoidosis,it remains to be further refined. Meantime,with continuous development of drugs,some biological agents can be employed to effectively treat sarcoidosis. In this article,research progress on drug treatment for sarcoidosis was reviewed. Glucocorticoid and immune-suppressants may be the key to the treatment of sarcoidosis. Biological agents are the focus of subsequent research.