Abstract: Primary biliary cholangitis （PBC） is a disease with unclear etiology and pathogenesis. In recent years,it has become a hot topic to identify the potential pathogenesis and therapeutic targets of PBC by studying the changes of metabolic substances in PBC patients. Metabonomics are employed to comprehensively analyze the metabolic spectrum of PBC patients through mass spectrometry and nuclear magnetic resonance technology,providing assistance for the diagnosis and treatment of PBC. In this article,recent research progress upon metabonomics in PBC was reviewed,aiming to provide new ideas for clinical diagnosis and treatment of PBC.