Abstract: Objective To investigate the clinical features and risk factors of sepsis-induced cardiomyopathy in children with sepsis, aiming to provide reference for enhancing the diagnosis and treatment levels of clinicians. Methods Clinical data of children with sepsis were retrospectively analyzed. All patients were divided into the sepsis-induced cardiomyopathy group and non-sepsis-induced cardiomyopathy group according to whether sepsis-induced cardiomyopathy occurred.Clinical characteristics and outcomes were compared between two groups. The risk factors of sepsis-induced cardiomyopathy were analyzed. Results Three hundred and ninty-eight children with sepsis were included in this study, and the incidence of sepsis-induced cardiomyopathy was 15.58%（62/398）. The age of children in the sepsis-induced cardiomyopathy group was 49 （18, 108） months, older than 19 （6, 52） months in the non-sepsis-induced cardiomyopathy group. The incidence of septic shock in the sepsis-induced cardiomyopathy group was 83.87%（52/62）, which was higher than 42.56% （143/336） in the non-sepsis-induced cardiomyopathy group. The mortality rate in the sepsis-induced cardiomyopathy group was 29.03% （18/62）, significantly higher than 14.58% （49/336） in the non-sepsis-induced cardiomyopathy group. All differences were statistically significant （all P < 0.05）.Multivariate Logistic regression analysis showed that the influence of age on sepsis-induced cardiomyopathy was statistically significant （OR=1.010, 95%CI 1.003-1.017, P = 0.006）. The higher the lactic acid level, the higher the risk of sepsis-induced cardiomyopathy, with statistical significance （OR=1.163, 95%CI 1.034-1.308, P = 0.012）. The higher the cTnI level, the higher the risk of sepsis-induced cardiomyopathy, with statistical significance （OR=9.929, 95%CI 4.651-21.197, P < 0.001）. Conclusions Compared with children with non-sepsis-induced cardiomyopathy, children with sepsis-induced cardiomyopathy are more prone to septic shock and have higher mortality. Age, lactic acid and cTnI levels are the independent influencing factors for sepsis-induced cardiomyopathy in children.