Abstract: ObjectiveTo investigate the relationship among the quality of life, parenting styles, and family quality in children after liver transplantation. MethodsOne hundred and thirty-six families of pediatric liver transplantation recipients admitted to the Third Affiliated Hospital of Sun Yat-sen University between April 2023 and February 2024 were enrolled. The study instruments included a general survey, the Pediatric Quality of Life Questionnaire 4.0 （PedsQL4.0）, Pediatric Quality of Life Family Impact Module （PedsQL^TMFIM） 2.0 and the Parenting Styles and Dimensions Questionnaire （PSDQ）. The correlation between family function, parental education style, and quality of life was analyzed by Pearson correlation analysis, and mediation effects were analyzed. ResultsPaternal authoritarian parenting styles were negatively correlated with the overall quality of life of pediatric recipients after liver transplantation （B=-0.93, 95%CI：-1.44 to -0.42） and family quality （B=-0.75, 95%CI： -1.31 to -0.18）. Family quality was significantly positively associated with the quality of life in children after liver transplantation （B=0.49, 95%CI： 0.35 to 0.62）. Mediating effect analysis revealed that paternal authoritarian parenting style could influence children’s quality of life after liver transplantation through family quality, and the direct effect was significant （direct effect=-0.64, 95%CI： -1.12 to -0.16）. ConclusionImproving parenting styles, especially reducing paternal authoritarian parenting styles, and elevating family quality are of significance for enhancing the quality of life in children after liver transplantation.