Abstract: Objective：To observe the therapeutic efficacy of Shenyan kangfu tablet combined with Valsartan in the treatment of diabetic nephropathy. Methods：98 cases of diabetic nephropathy stage 4 were randomly divided into two goups: 50 cases of Shenyan Kangfu Tablet combined with Valsartan group (combination group), and 48 cases of Valsartan group (ARB group). After 3 months of treatment, the differences in therapeutic efficacy was assessment, and blood pressure, plasma glucose and lipids, 24 hour urinary protein, plasma creatinine and alanine transarninase were measured. Results：The total therapeutic efficacy of combination group (84%) was significant higher than ARB group (70%) after 3 months of treatment. The level of 24 hour urinary protein in combination group ［（0.59±0.39）g］ was lower than in ARB group ［（0.98±0.57）g］. Both groups havn’t got obvious adverse reactions.Conclusion:Shenyan kangfu tablet combined with Valsartan maybe more effective to patients with late stage of diabetic nephropathy.