Abstract: Objective:To study the effect of insulin resistance and blood lipid abnormity in geriatric type 2 diabetic with early nephropathy. Methods:One hundred and fifty patients of geriatric type 2 diabetes?mellitus were divided into two groups based on the microalbuminuria urine albumin excretion (mUAE). They were early nephropathy group ( DN group) and non-nephropathy group ( DM group). The indexes of mUAE, insulin sensitivity index (ISI) and blood lipid were analyzed retrospectively. Results:The mUAE of the DN group ［（115±81）mg/24 h］ was significantly higher than the DM group［（17.±12）mg/24 h ］(P<0.01). The ISI of the DN group (-5.49±1.07) was significantly lower than the DM group (-5.00±0.62) (P<0.01). The?total cholesterol (TC), triglyceride (TG) and low?density?lipoprotein cholesterol (LDL-C) were respectively ［(4.76±1.43)mmol/L］, ［(1.78±1.10)mmol/L］ and［ (2.39±1.00)mmol/L］, which were［ (3.64±0.94)mmol/L］, ［(1.23±0.55)mmol/L］and［ (2.08±0.78)mmol/L］in the DM group. Those three indexes in the DN group were significantly higher than the DM group (P<0.01～P<0.05). The multivariate stepwise logistic regression analysis showed those independent risk factors associated with geriatric type 2 diabetic with early nephropathy were follow: IR, TC and TG. Conclusion：Insulin resistance and blood lipid abnormity have some influence on the occurrence and development of geriatric type 2 diabetic with early nephropathy.