Abstract: Objective：To evaluate the relationship between HLA-DR4 gene, clinical statistics, laboratory parameters of RA in Kazaks and Han patients in Xinjiang. Methods:The frequency of HLA-DR4 allele was determined in 122 Kazaks patients and 103 controls, using polymerase chain reaction sequence-specific(PCR-SSP), meanwhile 115 Han patients and 119 controls were also detected. Results: HLA-DR4 allele was more frequency in Kazaks and Han patients (P<0.01). There was no significant difference between DR4 and time of disease onset, disease duration, joint swelling counts, joint pain counts, DAS28 scores, and ESR、CRP、RF、CCP、AKA. There were more DR4 positive patients in Kazaks had bone erosron on X-ray(χ2=9.841，P=0.002), but not in Han RA group. Conclusions: HLA-DR4 is related with RA in both Kazaks and Han patients in Xinjiang. Erosion is more frequency in DR4 positive patients in Kazaks. More samples were needed.