Abstract: Objective：To investigate the protein expressions of Maspin and P53 in condyloma acuminatum lesions, and to explore their possible roles in the pathogenesis of condyloma acuminatum. Methods：In 67 cases of condyloma acuminatum and 20 normal prepuces lesions, protein expressions of Maspin and P53 were detected respectively by immunohistochemistry technique. Results：The positive rate of Maspin protein was significantly higher in condyloma acuminatum than in normal prepuces(85% vs 40%，P﹤0.01), while the positive rate of P53 protein was significantly lower in condyloma acuminatum than in normal prepuces(15% vs 55%，P﹤0.01). Conclusion：Low expression of Maspin and over-expression of P53 may play an important role in the pathogenesis of condyloma acuminatum, and contribut to cell proliferation of condyloma acuminatum.