Abstract: Objective To investigate the feasibility and safety of percutaneous endoscopic gastrostomy(PEG) and percutaneous endoscopic jejunostomy(PEJ). Methods Clinical date were retrospective analyzed from our hospital from January 2003 to January 2009. Thirty-three patients were treated with PEG, of which 5 patients were treated with PEG plus PEJ. Results Thirty-three cases of PEG, including five cases of PEG plus PEJ were successfully completed(performed). Three patients had the skin infections of abdominal fistula after PEG. One patient’s fistula had a small amount of bleeding. One patient had buried bumper syndrome. All patients had gradually improved after advancing nutritional support. Fourteen patients of repeated episodes of aspiration pneumonia before the operation were all cured by anti-infection. Conclusion PEG and PEJ are safe, efficient, convenient, economic, physiological and humane methods of enteral nutrition.