Abstract: Objective Explore the therapeutic effect of desmopressin and dry bed training in primary nocturnal enuresis. Method Eighty-seven chiildren with Primary Nocturnal Enuresis were randomly divied into 2 groups. Desmopressin group (51 cases) :treated by desmoprsessin and dry bed training for three months;Chinese medicine group (36 cases) :treated by Chinese medicine and dry bed training for three courses. Clinical efficacy and adverse effects were observed and compared. Result The effective rate was 88% in the desmopressin group and 67% in the chinese medicine group with a significant difference between the two groups(P<0.05).The reoccurrence rate was 36% in the desmopressin group and 50% in the chinese medicine group with a nosignificant difference between the two groups(P >0.05). Conclusion Desmopressin is effective and convenient and less side-effect in the treatment of PNE.