Abstract: objective This study was designed to investigate the effect of association of Tongxinluo and standard modern medicine treatment on serum oxidative stress, high sensitive C reactive protein（hsCRP）and vascular endothelial function in patients with ischemic cardiomyopathy(ICM).Methods Eighty-three patients with ICM were recruited to this study from 2008.9 to 2011.4. Patients were randomly divided into two groups: control group (n=41) and Tongxinluo treatment group (n=42).All subjects were followed up for 6 months. The levels of serum lipids, scavenging activity for superoxide anion radicals(O2-)，malondialdehyde, hsCRP, circulating Endothelial progenitor cells(EPC) and endothelial- derived microparticles (EMP) were examined in all subjects at enrollment and the end of study. The incidences of adverse reactions for medicines in two study groups were taken down. Results At the end of this study, the levels of serum malondialdehyde, hsCRP and circulating EMP were significantly decreased and serum scavenging activity for O2-, circulating EPC were significantly increased in Tongxinluo treatment group in comparison with control group, P<0.05. There were no significant differences between the two groups on the incidences of adverse reactions for medicines. Conclusions Tongxinlong might decrease the levels of serum oxidative stress, inflammation and improve the vascular endothelial function in patients with ICM.