Abstract: Objective To strengthen the clinical subjects physician to further understanding of the clinical characteristics and endoscopic appearances performance of the esophageal mucosa exfoliative in order to improve the accuracy of the initial diagnosis.Methods A retrospective analysis of our hospital decade admitted to hospital 29 patients with esophageal mucosa exfoliative disease ,a analysis of 29 cases on clinical and endoscopic examination and comprehensive. Results Twenty-nine cases were included in the analysis data from digestive medicine 16 cases,eight cases of gastrointestinal surgery,three cases of cardiology,otorhinolaryngology two cases.Which are clearly too fast eating 25 patients before the onset of the rough hard food or eating food containing bone foreign object history. All patients had varying degrees of nausea,vomiting pathogenesis.Patients are sudden persistent sternal pain as the first symptom,the pain got worse when swallowing even accompanied by difficulty in swallowing,followed by hematemesis, melena clinical performance.Two patients had spit in vomitting off-white striped film-like.Previous history of coronary heart disease,three patients were first diagnosed as coronary heart disease, which is a case of ECG prompt thrombolytic therapy acute anteroseptal myocardial ischemia in parallel,resulting in gastrointestinal bleeding intensified.All the patients were unable to obtain the correct diagnosis at a doctor first diagnosed.Conclusions Esophageal mucosa exfoliative disease clinical rare disease, acute onset,the incidence of multiple incentives,with characteristic clinical and endoscopic findings.Endoscopy is a necessary means for the diagnosis of esophageal mucosa exfoliative disease.The diagnosis was not difficult,the key for clinical physician and endoscopists is to have enough understanding to such disease.