Abstract: Objectives To present the initial experience of perineal radical prostatectomy in the treatment of local prostate cancer. Methods Two patients with local prostate cancer (T2a and T2c) received perineal radical prostatectomy, operative time, blood loss, catheter removal period, urinary continence were recorded. Results All 2 cases were completed successfully without conversion into retroperitoneal surgery. Operative time and blood loss were 175min and 200ml, 140min and 150ml for 2 patients, respectively. Cystography was take place on 7th day postoperatively and urinary catheter was removed after the exclusive of leakage. Pathological report indicated integrate prostate specimen and negative surgical margin. After 3-week follow-up, urine continence was excellent. Conclusion Perineal radical prostatectomy is safe and feasible and has a great advantage upon disease control and recovery of urinary continence.