Abstract: Objective：To investigate the effects of 3-hydroxy-3 -methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors simvastatin on brain natriuretic peptide (BNP) and ejection fraction (EF), in rats with ischemic heart failure. Methods：Healthy male SD rats with postoperative heart failure after surgery, were randomly selected and divided into control group and statin group, And eight healthy male SD rats were selected as sham group. Simvastatin was given 5 mg·kg-1·d-1 in stain group, while pure water was given in other groups. After 4 weeks of intragastric administration treatment, serum BNP concentration detection and EF measurement via ultrasound. Results：After 4 weeks, the BNP levels incresed in stain group and control gorup, meanwhile EF decreased, and the differences were statistical significance among three groups(P <0.05). The level of serum BNP in statin group was lower and EF higher than those in control group. Serum BNP levels and EF showed a negative correlation (r = －0.71, P <0.01). Serum BNP concentration of heart failure were reduced with ejection fraction increased Conclusion：Rats with ischemic heart failure received simvastatin treatment can significantly improve heart function.