Abstract: he increasing prevalence of diabetes constitutes a leading public health concern in Guangdong province. During the past 10 years, the prevalence of diabetes in adults aged 20 to 74 years increased from 3.5% in 1997 to 10.8% in 2007-2008. The more efforts are required for the prevention and treatment of diabetes. The comprehensive studies on diabetes mellitus were retrospectively reviewed during the past 10 years in Guangdong province. The present status was analyzed to find out the deficiency and the strategies.