Abstract: Objective: To investigate characteristics of lipid profiles and atherogenic index of plasma (AIP) in patients with newly diagnosed type 2 diabetes (T2DM), and to explore the effects of different intensive interventions on these parameters.
Methods: 382 patients with newly diagnosed T2DM and 68 people with normal glucose tolerance were included to assess the lipid profile, fasting plasma glucose, height, weight, waist and hip circumference. Intravenous glucose tolerance tests were carried out in patients with T2DM. Body mass index (BMI), waist-to-hip ratio (WHR), AIP（AIP = Log TG/HDL）, acute insulin response (AIR), HOMA-B and HOMA-IR were calculated. Patients in T2DM group were randomly assigned to therapy with insulin (CSII or MDI) or oral hypoglycaemic agents for initial rapid correction of hyperglycaemia. Treatment was stopped after normoglycaemia was maintained for 2 weeks. Baseline measurements were repeated after treatment. Results: Comparing with control group, proportion of dyslipidemia was significantly higher in T2DM (81.7% VS.67.6%，P＜0.01); triglyceride(TG) increased significantly (median: 1.75 mmol/L VS. 1.12 mmol/L, P＜0.01), so did AIP (0.19±0.32 VS. -0.01±0.29, P＜0.01). In T2DM group, AIP was significantly higher in male than that in female (0.23±0.33 VS.0.10±0.28, P＜0.01) and positively correlated with BMI, WHR, HOMA-IR, total cholesterol (TC), TG and LDL-C; while negatively correlated with HDL-C. Lipid profiles of T2DM patients were improved after 2-5 weeks of intensive hypoglycemic therapy with no significant difference among different treatment groups. Conclusion: There is high prevalence of dyslipidemia in patients with newly diagnosed T2DM presenting as increased TG and AIP. And AIP is positively correlated with indexes reflecting insulin resistance. Dyslipidemia and AIP of patients with newly diagnosed T2DM can be effectively improved by different short term intensive hypoglycemic interventions.