Abstract: Objective: To investigate the changes of neuroendocrine hormone and heart function in patients with slow arrhythmia treated by right ventricular inlet septum(RVIS) pacing. Methods: 56 patients treated with slow arrhythmia were treating with routine DDD pacemaker. Atrial pacing electrode implanted in the right atrial appendage comb muscle, ventricular leads implanted RVIS . At pacing and 6 months after the pacing therapy,: we measured the plasma content cyclic adenosine monophosphate(cAMP), cyclic guanosine monophosphate(cGMP), renin activity, angiotensin Ⅱ(Ang Ⅱ), aldosterone, B type natriuretic peptide and norepinephrine(NE); through color Doppler echocardiography, determined the heart function: cardiac output, stroke volume(SV), Left ventricular ejection fraction (LVEF), Left ventricular end diastolic diameter(LVDd) and left ventricular fractional shortening fraction(LVFS). Results：Six months after treatment of RVIS pacing, the neuroendocrine hormone: cAMP, cGMP, renin activity, Ang Ⅱ, aldosterone, Btype natriuretic peptide and NE levels decreased significantly during treatment compared with pacing; cardiac function significantly improved compared with pacing: cardiac output, SV, FS and LVEF increased, LVDd decreased. Conclusion：RVIS pacing can improve heart function, prevent heart failure and is worthy of promotion.