Abstract: Objective: To investigate the short-term effect of mobilization with movement（MWM） in Patients with lateral epicondylalgia. Method: Twenty seven subjects with lateral epicondylalgia were enrolled and were divided into MWM group(15 cases) and control group(12 cases). The patients of MWM group were treated with single MWM only once, and the patients of control group were treated with ultrashort wave (USW) and ultrasonic wave only once. Pain-free grip strength(PFG) and maximum grip strength(MGS) were measured before and after a single intervention.The visual analogue scales(VAS) before and after these treatment were also recorded for the suffering limbs.Result：In the MWM group，the PFG affected /MGS unaffected after the MWM was much higher than that before the MWM（0.80±0.18 vs. 0.55±0.20，P<0.05）, while it was much higher than that in the traditional physiotherapy treatment group（0.80±0.18 vs. 0.58±0.18，P<0.05）. The VAS after MWM was much lower than that after the traditional physiotherapy treatment（3.25±1.09 vs. 4.29±0.61，P<0.05）.Conclusion：MWM is a promising intervention modality for the treatment of patients with Lateral Epicondylalgia. It is effective in reducing pain, increasing active range of motion and promoting strength, and was worth of popularizing in the out-patient rehabilitation for the patients with lateral epicondylalgia .The underlying working mechanism needs more research.