Abstract: Objective:To investigate the clinical significance of interleukin-1β(IL-1β), interleukin-1 receptor antagonist (IL-1Ra), interleukin 10(IL-10), interleukin-6 (IL-6) and IL-1Ra/IL-1β, IL-10/IL-6 in coronary heart disease(CHD). Methods: Paitients with stable angina pectoris(SAP group, n=26), unstable angina pectoris (UAP group, n=26), and acute myocardial infarction (AMI group, n=27) were involved. Thirty healthy people were wers selected as control group. Enzyme-linked immunosorbent was used to detect the serum IL-1β, IL-1Ra, IL-10, IL-6, and the raito of IL-1Ra/IL-1β and IL-10/IL-6 were calcuated. Results: The serum IL-1Ra level of patients in UAP group and AMI group were significantly lower than that in control group, and IL-1β levels were significantly higher (P<0.05); IL-1Ra/IL-1β ratio in patients with CHD was lower than that in control group (P<0.05). The serum IL-10, IL-6 levels in patients with CHD were higher and IL-10/IL-6 ratio was lower than that of the control group (P<0.05). Conclusions:IL-1β, IL-1Ra, IL-10, IL-6 may be involved in the pathogenesis of CHD. IL-1Ra/IL-1β and IL-10/IL-6 in patients with CHD can reflect the immune adjustment. The degree and dynamics of the ratios are important to monitor the state of CHD.