Abstract: Objective: To compare the value of acute physiology and chronic health evaluationⅡ(APACHE Ⅱ) score，Ranson score and extrapancreatic inflammation on abdominal ?computed tomography(EPIC) score in predicting outcomes of patients with acute pancreatitis（AP）. Methods: One hundred and ninety-eight patients diagnosed as AP with completed data were studied. Among 198 patients，sixty were severe acute pancreatitis（SAP） and others were mild acute pancreatitis（MAP）. The value of APACHE Ⅱ score, Ranson score and EPIC score were assessed using by receiver operator characteristic（ROC）curve in predicting severity and complications of AP. Results：Among 198 patients, the APACHE Ⅱ score，Ranson score and EPIC score were significantly higher in SAP group than those in MAP group (all P＜0.01). EPIC score had the best sensitivity，specificity and the area under ROC curve (AUROC) for predicting SAP, and had the greatest AUROC to predict local complications. However, the APACHE Ⅱ score had the greatest AUROC to predict systemic complications. Conclusion：In patients with AP，combined EPIC score and APACHE Ⅱscore can estimate outcomes accurately within 24 h of admission, but the Ranson score has no advantages.