Abstract: Objective To evaluate the clinical efficacy of curettage with self-made subcutaneous separator in the treatment of axillary osmidrosis. Methods A total of 70 patients with axillary osmidrosis were divided into the study group （n = 35） and control group （n = 35）. In the study group, patients received curettage with self-made subcutaneous separator and those in the control group were treated with subcutaneous excision with a small incision. All patients were followed up 6 months after corresponding treatment. Cure rate, operation time, incidence rate of complications, postoperative recurrence rate and aesthetic appearance of incision were statistically compared between two groups. Results In the study group, the cure rate of axillary osmidrosis was significantly higher （80.0% vs. 45.7%, P < 0.05）, the operation time was remarkably shorter （（15.79±1.73）min vs.（34.65±5.83）min, P< 0.05）, the incidence rate of complications was considerably lower （5.7% vs. 25.7%, P < 0.05）, the recurrence rate was significantly lower （5.7% vs. 22.9%, P < 0.05） and the aesthetic appearance of incision was considerably better （P < 0.05） compared with those in the control group. Conclusion Curettage with self-made subcutaneous separator is an efficacious and safe treatment of axillary osmidrosis, which yields satisfactory aesthetic incisional appearance and a low incidence of postoperative complications.