Abstract: Granulicatella adiacens can cause infection in multiple sites, such as endocardium, bone marrow and joints, etc. Lack of standardized antimicrobial susceptibility test results increases the difficulty of treatment. In this article, clinical data of 1 patient with Granulicatella adiacens infection were reported. The 60-year-old male patient developed rapidly after admission and suffered from severe heart failure, septic shock and MODS. After active treatment such as anti-infection, renal replacement therapy, ventilator-assisted ventilation and other organ support therapy, the patient was still not treated and died at 60 h after admission to ICU. Blood culture result was Gram-positive cocci. The patient was diagnosed with Granulicatella adiacens septicemia. Literature review revealed that Granulicatella adiacens was generally sensitive to vancomycin, levofloxacin, clindamycin and meropenem. This case prompts that the disease progression of Granulicatella adiacens infection is extremely rapid. Clinicians should deepen their understanding of Granulicatella adiacens septicemia and enhance their cautions against infection-related bacteremia.