Abstract: Objective To investigate the effect of intraspinal labor analgesia on intrapartum anxiety/depression emotional disorders. Methods A total of 120 primiparae who delivered vaginally were selected as subjects, including 55 in the analgesia group, 47 in the non-analgesia group, and 18 pregnant women were excluded due to switching to cesarean section or intrapartum lost to follow-up. Face-to-face questionnaires were conducted at the first stage of labor （incubation period, active period）, the second, and the third stages of labor （including maternal demography, socioeconomic data, and standardized numerical pain rating scale, self-rating anxiety scale, and the Edinburgh postpartum depression scale）. The proportion of moderate to severe pain and the incidence of anxiety/depression emotional disorders were compared between the two groups. Results The proportion of moderate and severe pain in the first （incubation period, active period） and second stage of labor in the analgesia group was lower than that in the non-analgesia group （all P < 0.001）. The incidence of anxiety disorders in the active stage and the second stage of labor, and the incidence of depression disorders in the second stage of labor were lower in the analgesic group than in the non-analgesic group, and the differences were statistically significant （all P < 0.05）. Conclusion Intraspinal labor analgesia can relieve maternal anxiety and depression during childbirth.