Abstract: Radiation-induced oral mucositis （ROM） is a major complication of radiotherapy for nasopharyngeal carcinoma patients. The manifestations associated with ROM include oral mucosal pain, anorexia, odynophagia and secondary infections. Specifically, oral mucosal pain exerts extremely adverse impact on the quality of life and treatment process of patients. Therefore, rational and effective management of pain are of great significance. In recent years, clinical trials have been conducted to improve the survival benefit of cancer patients. In addition, application of opioids in treating ROM-induced pain in patients with nasopharyngeal carcinoma has been reported. In this article, research progress on the use of opioids in the treatment of ROM-induced pain in nasopharyngeal carcinoma patients was summarized.